SHAPE EXOCYTOSIS EFFICIENCY 4 IN CHICK AUDITORY HAIR CELLS DURING DEVELOPMENT 5 6 7 Abbreviated title : T - type and L - type Ca 2 + current in chick hair cells 8 9 10
نویسندگان
چکیده
IN CHICK AUDITORY HAIR CELLS DURING DEVELOPMENT 5 6 7 Abbreviated title: T-type and L-type Ca current in chick hair cells 8 9 10 Snezana Levic and Didier Dulon 11 12 Equipe Neurophysiologie de la Synapse Auditive, Unité Mixte de Recherche, Inserm 13 U587 et Université Bordeaux Segalen, Institut des Neurosciences de Bordeaux, Centre 14 Hospitalier Universitaire Pellegrin, 33076 Bordeaux, France. 15 16 17 Corresponding author: Didier Dulon at the above address: [email protected] 18 19 20 21 Author contributions: Conceived and designed the experiments: SL DD. Performed the 22 experiments: SL. Analyzed the data: SL DD. Contributed reagents/materials/analysis 23 tools: SL DD. Wrote the paper: SL DD. 24 25 26 27 Articles in PresS. J Neurophysiol (September 12, 2012). doi:10.1152/jn.00555.2012
منابع مشابه
The temporal characteristics of Ca entry through L-type and T-type Ca channels shape exocytosis efficiency in chick auditory hair cells during development
Levic S, Dulon D. The temporal characteristics of Ca entry through L-type and T-type Ca channels shape exocytosis efficiency in chick auditory hair cells during development. J Neurophysiol 108: 3116–3123, 2012. First published September 12, 2012; doi:10.1152/jn.00555.2012.— During development, synaptic exocytosis by cochlear hair cells is first initiated by patterned spontaneous Ca spikes and, ...
متن کاملThe temporal characteristics of Ca2+ entry through L-type and T-type Ca2+ channels shape exocytosis efficiency in chick auditory hair cells during development.
During development, synaptic exocytosis by cochlear hair cells is first initiated by patterned spontaneous Ca(2+) spikes and, at the onset of hearing, by sound-driven graded depolarizing potentials. The molecular reorganization occurring in the hair cell synaptic machinery during this developmental transition still remains elusive. We characterized the changes in biophysical properties of volta...
متن کاملMembrane properties of chick semicircular canal hair cells in situ during embryonic development.
The electrophysiological properties of developing vestibular hair cells have been investigated in a chick crista slice preparation, from embryonic day 10 (E10) to E21 (when hatching would occur). Patch-clamp whole-cell experiments showed that different types of ion channels are sequentially expressed during development. An inward Ca(2+) current and a slow outward rectifying K(+) current (I(K(V)...
متن کاملA mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea
Recent studies have demonstrated that the Notch signaling pathway regulates the differentiation of sensory hair cells in the vertebrate inner ear [1] [2] [3] [4] [5] [6] [7] [8] [9]. We have shown previously that in mice homozygous for a targeted null mutation of the Jagged2 (Jag2) gene, which encodes a Notch ligand, supernumerary hair cells differentiate in the cochlea of the inner ear [7]. Ot...
متن کاملDermo-epidermal interactions between birds and mammals: differentiation of cutaneous appendages.
1. The capacity of skin constituents to participate in feather and hair morphogenesis has been analysed in chick and mouse embryos. 2. Reconstituted homoand heterospecific skin explants, consisting of epidermis and dermis from both species, were cultured for 8 days on the chorioallantoic membrane of the chick. 3. Recombinants of dorsal 11-5and 125-day mouse epidermis and dorsal 7-day or tarsome...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012